{"id":5429,"date":"2024-03-12T16:50:23","date_gmt":"2024-03-12T15:50:23","guid":{"rendered":"https:\/\/afcytometrie.fr\/?post_type=evenement&p=5429"},"modified":"2024-03-12T16:50:25","modified_gmt":"2024-03-12T15:50:25","slug":"groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer","status":"publish","type":"evenement","link":"https:\/\/afcytometrie.fr\/en\/evenement\/groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer\/","title":{"rendered":"Groupe Cytom\u00e9trie de masse AFC : IL-12 and IL-23: paradoxical behavior in inflammation and cancer"},"content":{"rendered":"
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\"\"<\/figure>\n<\/div>\n\n\n

Le groupe de travail \u201cCytom\u00e9trie de masse” de l’Association Fran\u00e7aise de Cytom\u00e9trie est heureux de vous inviter \u00e0 son prochain webinaire :<\/p>\n\n\n\n

Le 28 Mars 2024 \u00e0 12h30<\/p>\n\n\n\n

IL-12 et IL-23 : comportement paradoxal dans l’inflammation et le cancer<\/strong><\/p>\n\n\n\n

Pr\u00e9sent\u00e9 par Pr. Burkhard Becher<\/strong><\/p>\n\n\n\n

University of Zurich,\u00a0Institute of\u00a0Experimental Immunology<\/p>\n\n\n\n

Lien Zoom<\/strong>: https:\/\/univ-amu-fr.zoom.us\/j\/81537671135?pwd=VzJkTUtFdWVTMm0weUZvaVE1NTE3dz09<\/a><\/p>\n\n\n\n

Code : 275002<\/p>\n\n\n\n

IL-12 and IL-23 are closely related cytokines and represent the most proinflammatory mediators of the IL-12 superfamily. Both cytokines are structurally similar and share both producing and sensing cell types. While IL-12 is a canonical TH type I inducing mediator, IL-23 is firmly linked with type III immunity. Both cytokines are considered central mediators of TH cell polarization and are linked with inflammation and even immunopathology. However, whilst IL-12 stimulates type 1 lymphocytes and can eliminate established tumors, the loss of IL-12 leads to drastically enhanced inflammation across various models of chronic inflammatory disease and autoimmunity. Likewise, IL-23, which plays a non-redundant function in the development of autoimmunity and type 3 immune responses, it also increases tumor growth. These at first glance paradoxically appearing properties form the focus of this presentation. I will discuss the discoveries around IL-12 and IL-23 from a historical perspective, taking into account the most recent findings on their immunoregulatory properties in the context of inflammation and cancer in particular and immunity in general.<\/em><\/p>\n","protected":false},"template":"","typesevenement":[58],"class_list":["post-5429","evenement","type-evenement","status-publish","hentry","typesevenement-webinars-groupes-thematiques-en"],"acf":[],"yoast_head":"\nGroupe Cytom\u00e9trie de masse AFC : IL-12 and IL-23: paradoxical behavior in inflammation and cancer - AFC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afcytometrie.fr\/en\/evenement\/groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Groupe Cytom\u00e9trie de masse AFC : IL-12 and IL-23: paradoxical behavior in inflammation and cancer - AFC\" \/>\n<meta property=\"og:description\" content=\"Le groupe de travail \u201cCytom\u00e9trie de masse” de l’Association Fran\u00e7aise de Cytom\u00e9trie est heureux de vous inviter \u00e0 son prochain webinaire : Le 28 Mars 2024 \u00e0 12h30 IL-12 et IL-23 : comportement paradoxal dans l’inflammation et le cancer Pr\u00e9sent\u00e9 par Pr. Burkhard Becher University of Zurich,\u00a0Institute of\u00a0Experimental Immunology Lien Zoom: https:\/\/univ-amu-fr.zoom.us\/j\/81537671135?pwd=VzJkTUtFdWVTMm0weUZvaVE1NTE3dz09 Code : 275002 IL-12 and IL-23 are closely related cytokines and represent the most proinflammatory mediators of the IL-12 superfamily. Both cytokines are structurally similar and share both producing and sensing cell types. While IL-12 is a canonical TH type I inducing mediator, IL-23 is firmly linked with type III immunity. Both cytokines are considered central mediators of TH cell polarization and are linked with inflammation and even immunopathology. However, whilst IL-12 stimulates type 1 lymphocytes and can eliminate established tumors, the loss of IL-12 leads to drastically enhanced inflammation across various models of chronic inflammatory disease and autoimmunity. Likewise, IL-23, which plays a non-redundant function in the development of autoimmunity and type 3 immune responses, it also increases tumor growth. These at first glance paradoxically appearing properties form the focus of this presentation. I will discuss the discoveries around IL-12 and IL-23 from a historical perspective, taking […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/afcytometrie.fr\/en\/evenement\/groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"AFC\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-12T15:50:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/afcytometrie.fr\/wp-content\/uploads\/2023\/05\/image-1-1024x657.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/afcytometrie.fr\/en\/evenement\/groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer\/\",\"url\":\"https:\/\/afcytometrie.fr\/en\/evenement\/groupe-cytometrie-de-masse-afc-il-12-and-il-23-paradoxical-behavior-in-inflammation-and-cancer\/\",\"name\":\"Groupe Cytom\u00e9trie de masse AFC : IL-12 and IL-23: paradoxical behavior in inflammation and cancer - 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Burkhard Becher University of Zurich,\u00a0Institute of\u00a0Experimental Immunology Lien Zoom: https:\/\/univ-amu-fr.zoom.us\/j\/81537671135?pwd=VzJkTUtFdWVTMm0weUZvaVE1NTE3dz09 Code : 275002 IL-12 and IL-23 are closely related cytokines and represent the most proinflammatory mediators of the IL-12 superfamily. Both cytokines are structurally similar and share both producing and sensing cell types. While IL-12 is a canonical TH type I inducing mediator, IL-23 is firmly linked with type III immunity. Both cytokines are considered central mediators of TH cell polarization and are linked with inflammation and even immunopathology. However, whilst IL-12 stimulates type 1 lymphocytes and can eliminate established tumors, the loss of IL-12 leads to drastically enhanced inflammation across various models of chronic inflammatory disease and autoimmunity. 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